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1

Neuroprotective effects of mGluR5 activation through the PI3K/Akt pathway and the molecular switch of AMPA receptors

Cavallo, Damiana, Landucci, Elisa, Gerace, Elisabetta, Lana, Daniele, Ugolini, Filippo, Henley, Jeremy M., Giovannini, Maria Grazia, Pellegrini-Giampietro, Domenico E.

Journal:

Neuropharmacology

Year:

2020

Language:

english

File:

PDF, 6.58 MB

english, 2020

2

Novel 3-Carboxy- and 3-Phosphonopyrazoline Amino Acids as Potent and Selective NMDA Receptor Antagonists: Design, Synthesis, and Pharmacological Characterization

Paola Conti, Andrea Pinto, Lucia Tamborini, Ulf Madsen, Birgitte Nielsen, Hans Bräuner-Osborne, Kasper B. Hansen, Elisa Landucci, Domenico E. Pellegrini-Giampietro, Giovambattista De Sarro, Eugenio Do

Journal:

Year:

2010

Language:

english

File:

PDF, 468 KB

english, 2010

3

1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3′-carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia

Domenico E. Pellegrini-Giampietro, Andrea Cozzi, Fiamma Peruginelli, Patrizia Leonardi, Elena Meli, Roberto Pellicciari, Flavio Moroni

Journal:

European Journal of Neuroscience

Year:

1999

Language:

english

File:

PDF, 594 KB

english, 1999

4

(+)-MCPG induces PKCε translocation in cortical synaptosomes through a PLD-coupled mGluR

L. Pastorino, F. Colciaghi, F. Gardoni, S. Albani-Torregrossa, D. E. Pellegrini-Giampietro, F. Moroni, P. N. E. De Graan, F. Cattabeni, M. Di Luca

Journal:

European Journal of Neuroscience

Year:

2000

Language:

english

File:

PDF, 427 KB

english, 2000

5

Lack of PSD-95 drives hippocampal neuronal cell death through activation of an αCaMKII transduction pathway

Fabrizio Gardoni, Camilla Bellone, Barbara Viviani, Marina Marinovich, Elena Meli, Domenico E. Pellegrini-Giampietro, Flaminio Cattabeni, Monica Di Luca

Journal:

European Journal of Neuroscience

Year:

2002

Language:

english

File:

PDF, 606 KB

english, 2002

6

NMDA and Non-NMDA Receptor Gene Expression Following Global Brain Ischemia in Rats: Effect of NMDA and Non-NMDA Receptor Antagonists

Domenico E. Pellegrini-Giampietro, William A. Pulsinelli, R. Suzanne Zukin

Journal:

Journal of Neurochemistry

Year:

1994

Language:

english

File:

PDF, 1.21 MB

english, 1994

7

The Metabotropic Glutamate Receptors, edited by P. J. Conn and J. Patel. Humana Press, Totowa, New Jersey, 1993, ISBN 0-89603-291-4, 300 pp., $99.50.

D. E. Pellegrini-Giampietro

Journal:

Journal of Neurochemistry

Year:

1995

Language:

english

File:

PDF, 81 KB

english, 1995

8

Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures

Raffaella Carpenedo, Elena Meli, Fiamma Peruginelli, Domenico E. Pellegrini-Giampietro, Flavio Moroni

Journal:

Journal of Neurochemistry

Year:

2002

Language:

english

File:

PDF, 219 KB

english, 2002

9

Differential role of mGlu1 and mGlu5 receptors in rat hippocampal slice models of ischemic tolerance

Claudia G. Werner, Tania Scartabelli, Tristano Pancani, Elisa Landucci, Flavio Moroni, Domenico E. Pellegrini-Giampietro

Journal:

European Journal of Neuroscience

Year:

2007

Language:

english

File:

PDF, 671 KB

english, 2007

10

Excitatory Amino Acid Release from Rat Hippocampal Slices as a Consequence of Free-Radical Formation

Domenico E. Pellegrini-Giampietro, Giovanna Cherici, Marina Alesiani, Vincenzo Carlà, Flavio Moroni

Journal:

Journal of Neurochemistry

Year:

1988

Language:

english

File:

PDF, 375 KB

english, 1988

11

GAT-1 regulates both tonic and phasic GABAA receptor-mediated inhibition in the cerebral cortex

Luca Bragina, Ivan Marchionni, Azar Omrani, Andrea Cozzi, Domenico E. Pellegrini-Giampietro, Enrico Cherubini, Fiorenzo Conti

Journal:

Journal of Neurochemistry

Year:

2008

Language:

english

File:

PDF, 719 KB

english, 2008

12

Activation of the histaminergic H3 receptor induces phosphorylation of the Akt/GSK-3β pathway in cultured cortical neurons and protects against neurotoxic insults

Chiara Mariottini, Tania Scartabelli, Gerold Bongers, Silvia Arrigucci, Daniele Nosi, Rob Leurs, Alberto Chiarugi, Patrizio Blandina, Domenico E. Pellegrini-Giampietro, Maria Beatrice Passani

Journal:

Journal of Neurochemistry

Year:

2009

Language:

english

File:

PDF, 558 KB

english, 2009

13

Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage

F Moroni, L Formentini, E Gerace, E Camaioni, D E Pellegrini-Giampietro, A Chiarugi, R Pellicciari

Journal:

British Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 383 KB

english, 2009

14

Long-lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP-ribose) polymerase

F Moroni, A Cozzi, A Chiarugi, L Formentini, E Camaioni, DE Pellegrini-Giampietro, Y Chen, S Liang, MM Zaleska, C Gonzales, A Wood, R Pellicciari

Journal:

British Journal of Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.66 MB

english, 2012

15

Neuroprotective Effects of Propofol in Acute Cerebral Injury

Chiara Adembri, Luna Venturi, Domenico E. Pellegrini-Giampietro

Journal:

CNS Drug Reviews

Year:

2007

Language:

english

File:

PDF, 803 KB

english, 2007

16

Topiramate concentrations in neonates treated with prolonged whole body hypothermia for hypoxic ischemic encephalopathy

Luca Filippi, Giancarlo La Marca, Patrizio Fiorini, Chiara Poggi, Giacomo Cavallaro, Sabrina Malvagia, Domenico E. Pellegrini-Giampietro, Renzo Guerrini

Journal:

Year:

2009

Language:

english

File:

PDF, 299 KB

english, 2009

17

Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death

Domenico E. Pellegrini-Giampietro, Guido Mannaioni, Giacinto Bagetta

Journal:

Year:

2009

Language:

english

File:

PDF, 187 KB

english, 2009

18

Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia

Moroni, F, Meli, E, Peruginelli, F, Chiarugi, A, Cozzi, A, Picca, R, Romagnoli, P, Pellicciari, R, Pellegrini-Giampietro, D E

Journal:

Cell Death & Differentiation

Year:

2001

Language:

english

File:

PDF, 473 KB

english, 2001

19

The expression of glutamate transporter GLT-1 in the rat cerebral cortex is down-regulated by the antipsychotic drug clozapine

Pellegrini-Giampietro, D E, Rothstein, J D, Conti, F, Melone, M, Vitellaro-Zuccarello, L, Vallejo-Illarramendi, A, Pérez-Samartin, A, Matute, C, Cozzi, A

Journal:

Molecular Psychiatry

Year:

2001

Language:

english

File:

PDF, 700 KB

english, 2001

20

Metabotropic Glutamate Receptors Stimulate Phospholipase D via Different Pathways in the Adult and Neonate Rat Hippocampus

Sabina Attucci, Serenella Albani-Torregrossa, Flavio Moroni, Domenico E. Pellegrini-Giampietro

Journal:

Neurochemical Research

Year:

2001

Language:

english

File:

PDF, 45 KB

english, 2001

21

Biochemical and behavioural studies on indole-pyruvic acid: a keto-analogue of tryptophan

L. Bacciottini, D.E. Pellegrini-Giampietro, F. Bongianni, G. de Luca, V. Politi, F. Moroni

Journal:

Pharmacological Research Communications

Year:

1987

Language:

english

File:

PDF, 679 KB

english, 1987

22

Studies on the role of calcium and phospholipase in the morphine withdrawal syndrome

Domenico E. Pellegrini-Giampietro, Giovanna Cherici, Flavio Moroni

Journal:

Pharmacological Research Communications

Year:

1988

Language:

english

File:

PDF, 78 KB

english, 1988

23

Phospholipase C activation during morphine withdrawal

G. Cherici, M. Alesiani, D.E. Pellegrini-Giampietro, F. Moroni

Journal:

Pharmacological Research Communications

Year:

1988

Language:

english

File:

PDF, 71 KB

english, 1988

24

Release of excitatory amino acids “In vitro” by free radicals

D.E. Pellegrini-Giampietro, G. Cherici, V. Carlà, F. Moroni

Journal:

Pharmacological Research Communications

Year:

1988

Language:

english

File:

PDF, 71 KB

english, 1988

25

Activation of mGlu1 but not mGlu5 metabotropic glutamate receptors contributes to postischemic neuronal injury in vitro and in vivo

Elena Meli, Roberta Picca, Sabina Attucci, Andrea Cozzi, Fiamma Peruginelli, Flavio Moroni, Domenico E. Pellegrini-Giampietro

Journal:

Pharmacology Biochemistry and Behavior

Year:

2002

Language:

english

File:

PDF, 145 KB

english, 2002

26

Mild activation of poly(ADP-ribose) polymerase (PARP) is neuroprotective in rat hippocampal slice models of ischemic tolerance

Elisabetta Gerace, Tania Scartabelli, Laura Formentini, Elisa Landucci, Flavio Moroni, Alberto Chiarugi, Domenico E. Pellegrini-Giampietro

Journal:

European Journal of Neuroscience

Year:

2012

Language:

english

File:

PDF, 2.24 MB

english, 2012

27

A NEW ENDOGENOUS ANXIOLYTIC AGENT: l-PYROGLUTAMIC ACID

M. BENI, D.E. PELLEGRINI-GIAMPIETRO, F. MORONI

Journal:

Fundamental & Clinical Pharmacology

Year:

1988

Language:

english

File:

PDF, 316 KB

english, 1988

28

Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus

Domenico E. Pellegrini-Giampietro, Serenella Albani Torregrossa, Flavio Moroni

Journal:

British Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.82 MB

english, 1996

29

Lesioning and recovery of the serotoninergic projections to the hippocampus

G. Lombardi, O. Gandolfi, R. Dall'Olio, D.E. Pellegrini-Giampietro, M. Beni, V. Carla, A. Consolazione, F. Moroni

Journal:

Year:

1987

Language:

english

File:

PDF, 553 KB

english, 1987

30

Morphine withdrawal in vitro: Potentiation of agonist-dependent polyphosphoinositide breakdown

Domenico E. Pellegrini-Giampietro, Marco Ruggiero, Stefano Giannelli, Vincenzo P. Chiarugi, Flavio Moroni

Journal:

European Journal of Pharmacology

Year:

1988

Language:

english

File:

PDF, 730 KB

english, 1988

31

Glycine and kynurenate modulate the glutamate receptors in the myenteric plexus and in cortical membranes

Flavio Moroni, Domenico E. Pellegrini-Giampietro, Marina Alesiani, Giovanna Cherici, Francesca Mori, Alessandro Galli

Journal:

European Journal of Pharmacology

Year:

1989

Language:

english

File:

PDF, 234 KB

english, 1989

32

Pharmacological studies on new agonists and antagonists of mGluRs

F. Moroni, G. Lombardi, D.E. Pellegrini-Giampietro, P. Leonardi, S. Attucci, G. Mannaioni, F. Peruginelli, S. Albani, C. Thomsen, R. Pellicciari

Journal:

Neuropharmacology

Year:

1996

Language:

english

File:

PDF, 132 KB

english, 1996

33

Metabotropic glutamate receptors coupled to phospholipase D

D.E. Pellegrini-Giampietro, S. Albani, R. Pellicciari, F. Moroni

Journal:

Neuropharmacology

Year:

1996

Language:

english

File:

PDF, 145 KB

english, 1996

34

Differential role of poly(ADP-ribose) polymerase-1in apoptotic and necrotic neuronal death induced by mild or intense NMDA exposure in vitro

Elena Meli, Marilena Pangallo, Roberta Picca, Roberto Baronti, Flavio Moroni, Domenico E Pellegrini-Giampietro

Journal:

Molecular and Cellular Neuroscience

Year:

2004

Language:

english

File:

PDF, 493 KB

english, 2004

35

NAPOR-3 RNA binding protein is required for apoptosis in hippocampus

Alessandra Pacini, Annarita Toscano, Valentina Cesati, Andrea Cozzi, Elena Meli, Lorenzo Di Cesare Mannelli, Ferdinando Paternostro, Paolo Pacini, Domenico E. Pellegrini-Giampietro

Journal:

Molecular Brain Research

Year:

2005

Language:

english

File:

PDF, 701 KB

english, 2005

36

Group I metabotropic glutamate receptors stimulate the activity of poly(ADP-ribose) polymerase in mammalian mGlu1-transfected cells and in cortical cell cultures

Elena Meli, Roberto Baronti, Marilena Pangallo, Roberta Picca, Flavio Moroni, Domenico E. Pellegrini-Giampietro

Journal:

Neuropharmacology

Year:

2005

Language:

english

File:

PDF, 316 KB

english, 2005

37

mGlu1α receptors are co-expressed with CB1 receptors in a subset of interneurons in the CA1 region of organotypic hippocampal slice cultures and adult rat brain

Francesca Boscia, Francesco Ferraguti, Flavio Moroni, Lucio Annunziato, Domenico E. Pellegrini-Giampietro

Journal:

Neuropharmacology

Year:

2008

Language:

english

File:

PDF, 4.52 MB

english, 2008

38

Neuroprotection by group I mGlu receptors in a rat hippocampal slice model of cerebral ischemia is associated with the PI3K–Akt signaling pathway: A novel postconditioning strategy?

Tania Scartabelli, Elisabetta Gerace, Elisa Landucci, Flavio Moroni, Domenico E. Pellegrini-Giampietro

Journal:

Neuropharmacology

Year:

2008

Language:

english

File:

PDF, 1022 KB

english, 2008

39

CB1 receptors and post-ischemic brain damage: Studies on the toxic and neuroprotective effects of cannabinoids in rat organotypic hippocampal slices

Elisa Landucci, Tania Scartabelli, Elisabetta Gerace, Flavio Moroni, Domenico E. Pellegrini-Giampietro

Journal:

Neuropharmacology

Year:

2011

Language:

english

File:

PDF, 1.22 MB

english, 2011

40

The novel and systemically active metabotropic glutamate 1 (mGlu1) receptor antagonist 3-MATIDA reduces post-ischemic neuronal death

Flavio Moroni, Sabina Attucci, Andrea Cozzi, Elena Meli, Roberta Picca, Mark A Scheideler, Roberto Pellicciari, Christian Noe, Iran Sarichelou, Domenico E Pellegrini-Giampietro

Journal:

Neuropharmacology

Year:

2002

Language:

english

File:

PDF, 279 KB

english, 2002

41

Metabotropic glutamate 1 (mGlu1) receptor antagonists enhance GABAergic neurotransmission: a mechanism for the attenuation of post-ischemic injury and epileptiform activity?

Andrea Cozzi, Elena Meli, Vincenzo Carlà, Roberto Pellicciari, Flavio Moroni, Domenico E Pellegrini-Giampietro

Journal:

Neuropharmacology

Year:

2002

Language:

english

File:

PDF, 280 KB

english, 2002

42

Protection with metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death: time-course and mechanisms

Domenico E. Pellegrini-Giampietro, Fiamma Peruginelli, Elena Meli, Andrea Cozzi, Serenella Albani-Torregrossa, Roberto Pellicciari, Flavio Moroni

Journal:

Neuropharmacology

Year:

1999

Language:

english

File:

PDF, 934 KB

english, 1999

43

The distinct role of mGlu1 receptors in post-ischemic neuronal death

Domenico E Pellegrini-Giampietro

Journal:

Trends in Pharmacological Sciences

Year:

2003

Language:

english

File:

PDF, 1.11 MB

english, 2003

44

An activity-dependent spermine-mediated mechanism that modulates glutamate transmission

Domenico E Pellegrini-Giampietro

Journal:

Trends in Neurosciences

Year:

2003

Language:

english

File:

PDF, 292 KB

english, 2003

45

The GluR2 (GluR-B) hypothesis: Ca2+-permeable AMPA receptors in neurological disorders

Domenico E. Pellegrini-Giampietro, Jan A. Gorter, Michael V.L. Bennett, R.Suzanne Zukin

Journal:

Trends in Neurosciences

Year:

1997

Language:

english

File:

PDF, 592 KB

english, 1997

46

Reply - To comment letter by Ben-Ari (The GluR2 Hypothesis..)

D.E Pellegrini-Giampietro, R.S Zukin, J.A Gorter, M.V.L Bennett

Journal:

Trends in Neurosciences

Year:

1998

Language:

english

File:

PDF, 64 KB

english, 1998

47

Transient focal ischemia triggers neuronal expression of GAT-3 in the rat perilesional cortex

Marcello Melone, Andrea Cozzi, Domenico E Pellegrini-Giampietro, Fiorenzo Conti

Journal:

Neurobiology of Disease

Year:

2003

Language:

english

File:

PDF, 1.35 MB

english, 2003

48

Calcium channel inhibitors suppress the morphine-withdrawal syndrome in rats

F. Bongianni, V. Carla', F. Moroni, D.E. Pellegrini-Giampietro

Journal:

British Journal of Pharmacology

Year:

1986

Language:

english

File:

PDF, 962 KB

english, 1986

49

Morphine withdrawal in cortical slices: suppression by Ca2+-channel inhibitors of abstinence-induced [3H]-noradrenaline release

Domenico E. Pellegrini-Giampietro, Lucia Bacciottini, Vincenzo Carlà, Flavio Moroni

Journal:

British Journal of Pharmacology

Year:

1988

Language:

english

File:

PDF, 807 KB

english, 1988

50

Quinoxalines interact with the glycine recognition site of NMDA receptors: studies in guinea-pig myenteric plexus and in rat cortical membranes

Domenico E. Pellegrini-Giampietro, Alessandro Galli, Marina Alesiani, Giovanna Cherici, Flavio Moroni

Journal:

British Journal of Pharmacology

Year:

1989

Language:

english

File:

PDF, 752 KB

english, 1989